Clinical Trials Resource Unit

Director: Prof. John Armstrong, Consultant Radiation Oncologist.

The Clinical Trials Resource Unit (CTRU) is available to support all approved clinical trials taking place in St. Luke's Hospital. It provides some core administrative services including data management and statistical support. The CTRU also provides bookable office space as required for trial development, management, publication preparation, etc.

Our current portfolio includes trials in the areas of prostate, lung, spinal cord compression, head & neck and breast cancer. We also have some translational studies.

Prostate

A randomised trial comparing the bladder volume consistency achieved with two bladder-filling protocols in prostate conformal radiotherapy.
ICORG 05-04..

A prospective phase II dose escalation trial using IMRT and IGRT for T1a-T3c, N0, M0 prostate cancer. ICORG 08-17.

CHHiP - Conventional or hypofractionated high dose intensity modulated radiotherapy prostate cancer.
ICORG 08-18.

Lung

Radiation dose escalation for non-small cell lung cancer using hypofractionated 3-dimensional conformal radiation therapy.
ICORG 99-09

Prospective evaluation of PET-CT scan in patients with non-operable or non-resectable NSCLC treated by radical 3-DCRT.
ICORG 06-35.

A clinical trial using 3-DCRT to reduce the toxicity of palliative radiation for lung cancer.
ICORG 06-34.

Spinal Cord Compression

A randomised phase III trial of two fractionation schemes in the treatment of malignant spinal cord compression.
ICORG 05-03.

A phase II trial evaluating the efficacy of a radio-biological based re-irradiation strategy for patients with malignant spinal cord compression.
ICORG 07-11.

Head & Neck

A prospective randomised controlled clinical trial to evaluate standard versus customised headrests for head and neck radiotherapy patients.
ICORG 08-09.

Breast

Phase II randomised clinical trial of accelerated partial breast irradiation (APBI) comparing 3-dimensional conformal radiation therapy and multi-catheter interstitial brachytherapy.
ICORG 06-33.

NSABP B-39. A randomised phase III study of conventional whole breast irradiation (WBI) versus partial breast irradiation (PBI) for women with stage 0, I or II breast cancer.
ICORG 08-06.

Translational

Proteomic analysis of combined hormonal therapy and radiation therapy of intermediate risk localised prostate cancer.
ICORG 06-15.

Collaborative project on potential serum markers for malignant melanoma, metastatic breast, advanced lung, pancreatic carcinoma and colorectal cancer.
ICORG 07-12.